Thursday, Nov 27, 2014
 
search SGN
SERVING SEATTLE AND THE PACIFIC NORTHWEST FOR 40 YEARS!

click to visit advertiser's website


Javascript DHTML Drop Down Menu Powered by dhtml-menu-builder.com

Last Weeks Edition
   
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website




 

 
 

 

 

[Valid RSS]

click to go to advertisers website
to Section One | to Arts & Entertainment
posted Friday, March 21 2014 - Volume 42 Issue 12
New study on effects of meth use on HIV-positive men
Section One
ALL STORIES
  next story
New study on effects of meth use on HIV-positive men

by Mike Andrew - SGN Staff Writer

A new study by researchers at the University of California San Diego (UCSD) indicates that meth - unlike other party drugs - has a negative impact on the health of HIV-positive men, even when they are on antiretrovirals and have an undetectable viral load.

It has been known that HIV-positive people who use meth have a higher risk of cognitive impairment and faster progression to AIDS than those who do not.

The reason for this association is unclear, however. It may be that meth use impedes patients' adherence to their medication regimen, it may be that meth-related risk behaviors lead to worse outcomes, or it may be that there are physiological factors that explain the differences.

To address these questions, UCSD researchers evaluated use of methamphetamine and other recreational drugs in 50 men who have sex with men (MSM) with a viral load below 50 copies and on long-term antiretroviral therapy.

Their conclusion was that men who used meth had greater T-cell activation and proliferation than nonusers, meaning greater HIV activity, even though they had an undetectable viral load. The study also produced evidence that meth users may have a deeper DNA reservoir of HIV than nonusers.

Use of other recreational drugs did not have a significant impact on levels of immunologic or virologic markers.

The study went on for one year, and the subjects were asked to complete a monthly internet-based questionnaire about antiretroviral adherence and recreational drug use.

The UCSD researchers defined 'meth use' as reporting use in at least one survey over the one-year study period. They used frozen peripheral blood mononuclear cells (PBMCs) to assess standard markers of immune cell activation and proliferation and to measure total HIV DNA and cellular HIV RNA.

The men in the study averaged 46 years in age and had taken antiretrovirals for an average 4 years. Forty-two percent of the subjects were white, 20% were black, and 4% Hispanic. CD4 counts averaged 637, and all men had a viral load below 50 copies. Sixteen men reported using meth, 20 marijuana, 13 other club drugs, 12 alcohol, and 11 cocaine.

Men who used meth did not differ from nonusers in age, length of time on antiretrovirals, T-cell counts or sexually transmitted infections. Meth users and nonusers also did not differ in self-reported adherence to antiretrovirals.

However, meth users had significantly higher cytomegalovirus (CMV) shedding in semen, a trend toward more HIV shedding in semen, and a trend toward a lower CD4/CD8 ratio, which is considered a negative health outcome.

Compared with men who did not use meth, those who did had significantly higher levels of activated T-cells, and proliferating T-cells, including both CD4 and CD8 cells.

Increased proliferation of all T-cell subsets analyzed (naive, central memory, transitional memory, effector memory CD8s) suggested to the investigators 'a general and unspecific effect of meth in these cells in vivo,' that is in living patients.

The impact of meth use on T-cell activation and proliferation, the researchers proposed, 'could explain meth-related co-morbidities' in HIV-positive people who use meth.

The trend toward a deeper DNA reservoir and more HIV RNA in seminal plasma among meth users, the UCSD team speculated, 'could explain increased HIV transmission and worse HIV disease progression' in meth users.

Tell a friend:

Share on Facebook  Share on Facebook

Post to MySpace!Share on MySpace!

    Share on Delicious

Share on StumbleUpon!

Man burned in KOMO chopper crash is a member of the Gay community
------------------------------
Panel says Department of Defense regulations banning Transgender military service are outdated
------------------------------
Patty Murray, Maria Cantwell, Jim McDermott, Adam Smith sign letter on anti-LGBT discrimination
------------------------------
Jesse's Journal: Norm Kent: Publisher and Activist
------------------------------
Anti-Gay Mark Miloscia comes out as Republican
------------------------------
Race is on for 37th District Senate seat
------------------------------
Most conservative Washington state Supreme Court Justice to retire
------------------------------
Tennessee appeals marriage ruling
------------------------------
CDC warns about antibiotic-resistant gonorrhea
------------------------------
All Pilgrims offers FREE Recovery, Intimacy and Relationships Workshop.
------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------
BREAKING NEWS
------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

click to visit advertiser's website

click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
Seattle Gay Blog post your own information on
the Seattle Gay Blog
 

gay news feeds gay news readers gay rss gay
http://sgn.org/rss.xml | what is RSS? | Add to Google use Google to set up your RSS feed
SGN Calendar For Mobile Phones http://sgn.org/rssCalendarMobile.xml
SGN Calendar http://sgn.org/rssCalendar.xml

Seattle Gay News - SGN
1605 12 Ave., Ste. 31
Seattle, WA 98122

Phone 206-324-4297
Fax 206-322-7188

email: sgn2@sgn.org
website suggestions: web@sgn.org

copyright Seattle Gay News - DigitalTeamWorks 2013

USA Gay News American News American Gay News USA American Gay News United States American Lesbian News USA American Lesbian News United States USA News
Pacific Northwest News in Seattle News in Washington State News